X-Factor has returned from Las Vegas and is ready for business as usual. And for the world's premier mutant detective agency, business as usual is anything but usual! A trio of lovely but lethal lasses has its sights on arguably the biggest target in New York City, with inarguably its biggest mouth: Mayor J. Jonah Jameson! To solve this caper, X-Factor will need every bit of luck it can get--so whose side is the Black Cat on? Meanwhile, Darwin hits the road for parts unknown and runs afoul of a mystical gunslinger, a case involving a vampire gets X-Factor a little bloody, and did Jamie really ask Layla to marry him? Plus: new developments in the love triangle/baby-daddy drama between Rictor, Shatterstar and sweet little Rahne Sinclair. If the secrets Shatterstar learned in Vegas come out, then who knows how Rahne will react!