Collects Ultimate Spider-Man (2000) #46, Ultimate Six (2000) #1-7.
What happens when Green Goblin, Doctor Octopus, the Sandman, Electro and Kraven the Hunter escape a S.H.I.E.L.D. containment center and join forces? Who will they target as the sixth member of their deadly alliance? Spider-Man must do whatever it takes to stop them, but even with the help of the Ultimates, will that be enough?