Frank Fisher is nothing. He wants to be something. When Bonnie -- a mysterious, chain-smoking "muse" -- offers assistance by injecting literal seeds of inspiration directly into his brain through a festering wound, his world is changed forever. In "Tyranny of the Muse," the couple find themselves on a twisted path littered with addiction, self-loathing, and surreal romance. Through it all, they rely only on each other as they search for the endlessly elusive "somethingness."