The Twenty-Fourth Floor
Introducing TransCat! America's first transgender superhero! (except for Shvaughn Erin of the Legion Of Superheroes, and like... several others), But at the very least, the first transgender superhero who is the lead character of her own series (except for Ranma 1/2).
Anyway, follow TransCat's adventures as she fights tirelessly against the patriarchy, and somehow manages to keep her grades up and a love life going at the same time! Phew!