Hero Killer: Hope is Lost begins 18 months after the events of Hero Killer, where a depraved serial killer began his murderous spree of Earth’s superheroes. The world is now a very different place! The heroes struggle to keep order on America’s streets due to panic that so many heroes deaths has caused. Things will not get any easier, however, as the killer sets his sights on another one of Earth’s defenders. Somehow despite all this, Marquez’s life has changed for the better and she is eager to catch the killer that has sent the world into chaos.