The Defenders find their way to Wakanda and team with the Black Panther to face the lethal John Aman, the Prince of Orphans! What is Aman protecting that's worth killing so many for so long? And just how is Felicia Hardy, the Black Cat, going to steal it? Then: the Defenders are lost in space-time! What alternate universe will they find first ... and who is waiting for them? Finally, when the purpose of the Concordance engines are revealed, the team must act fast to save everything! What are the Death Celestials? How can the Defenders even hope to stop them? And how can you save the world when you can't tell anyone it's about to end?