John "The Hand" Smith may have escaped the jeweled jaws of Diamond Jack, but his troubles only seem to multiply. Someone is hell bent on seeing Smith and his oversized northpaw dispatched to their maker. But what doesn't kill him only seems to make him stronger, and Smith convinces Boss Madden to undertake a dangerous plan to rob the Chinese gangs of their opium, only to sell it back at an enormous profit. But double-crossings and Tommy guns wreak havoc on the Madden Crime Organization and just as things go from bad to worse, Madden's girl, Cora, starts to wonder if what they say about men with big hands is really true.
