Frank Fisher is nothing. He wants to be something. When bonnie, a mysterious, chain-smoking "muse," offers assistance by injecting seeds of inspiration directly into his brain through a festering wound, his world is changed forever. In Tyranny of the Muse, the couple find themselves on a twisted path littered with addiction, self-loathing, fear and surreal romance. Through it all, they rely only on each other as they endlessly search for the endlessly elusive "somethingness."