Pulled out of exile from a dark corner of the world, renowned-surgeon-turned-fringe-medicine-eccentric Dr. Randal Horne must return to New York City to investigate a tragic research lab accident that's left one man dead… and inexplicably headless. With the help of a distrusting NYPD detective, Horne must diagnose whether this strange case was truly a random act of misfortune, or the first calculated move by an invisible, psychotic murderer.